Cancer has been characterized as a genetic disease, associated with mutations that cause
pathological alterations of the cell cycle, adhesion, or invasive motility. Recently, the …

B-type lamins are fundamental components of the nuclear lamina, a complex structure that
acts as a scaffold for organization and function of the nucleus. Lamin B1 and B2, the most …

Widespread changes to DNA methylation and chromatin are well documented in cancer, but
the fate of higher-order chromosomal structure remains obscure. Here we integrated …

The capability to directly interrogate intracellular structures inside a single cell for
measurement and manipulation is important for understanding subcellular and suborganelle …

Simple Summary The aim of this review is to summarize lamin A/C's currently known
functions in both normal and diseased cells. Lamin A/C is a nuclear protein with many …

Extracellular forces transmitted through the cytoskeleton can deform the cell nucleus. Large
nuclear deformations increase the risk of disrupting the integrity of the nuclear envelope and …

Abstract Long interspersed elements-1 (LINE-1, L1) are retrotransposons that hold the
capacity of self-propagation in the genome with potential mutagenic outcomes. How somatic …

The A-type lamins (lamin A/C), encoded by the LMNA gene, are important structural
components of the nuclear lamina. LMNA mutations lead to degenerative disorders known …

Telomere maintenance is essential to preserve genomic stability and involves telomere-
specific proteins, DNA replication and repair proteins. Lamins are key components of the …

Upcoming technologies enable routine collection of highly multiplexed (20–60 channel),
subcellular resolution images of mammalian tissues for research and diagnosis. Extracting …