A steady decline in the fertility rate has been observed in Qatar during the past fifty years.
Therefore, infertility is considered a national priority in Qatar, a pronatalist society. This …

Arab populations are largely understudied, notably their genetic structure and history. Here
we present an in-depth analysis of 6,218 whole genomes from Qatar, revealing extensive …

Infertility is a common, clinically heterogeneous reproductive disorder worldwide with a
prevalence of about 15%. To date about eighty genes have been discovered to cause non …

Recessive mutations in Post-GPI attachment to proteins 3 (PGAP3) cause the rare
neurological disorder hyperphosphatasia with mental retardation syndrome 4 type …

We discuss the current state of genomic medicine in Arab countries of the Middle East, a
region with outsized contribution to Mendelian genetics due to inbreeding yet has poor …

Background Genome sequencing of large biobanks from under-represented ancestries
provides a valuable resource for the interrogation of Mendelian disease burden at world …

Background Although defects in sperm morphology and physiology lead to male infertility, in
many instances, the exact disruption of molecular pathways in a given patient is often …

Genetic diseases are a major cause of neonatal morbidity and mortality. The clinical
differential diagnosis in severely ill neonates, especially in premature infants, is challenging …

Human spermatogenesis is a qualitatively and quantitatively different process than that
observed for most other mammals. In contrast with most other mammals, human …

More than 25 million DNA variations have been discovered as novel including major alleles
from the Arab population. Exome studies on the Saudi genome discovered> 3000 novel …