The art of transforming peptides into drug leads is still a dynamic and fertile field in medicinal
chemistry and drug discovery. Peptidomimetics can respond to peptide limitations by …

Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus
making the development of PPI inhibitors extremely valuable. The identification of selective …

The indole nucleus is an important element of many natural and synthetic molecules with
significant biological activity. This review covers some of the relevant and recent …

The decreasing number of approved drugs produced by the pharmaceutical industry, which
has been accompanied by increasing expenses for R&D, demands alternative approaches …

The breadth of structure and function displayed by the molecules of biology is remarkable.
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …

Functions and properties of native peptides vary from highly specific antibiotics or cytotoxic
antitumor drugs, to hormones, neurotransmitters, immunomodulators, etc. Despite their …

Cyclic peptides are promising scaffolds for drug development, attributable in part to their
increased conformational order compared to linear peptides. However, when optimizing the …

The demand for modified peptides with improved stability profiles and pharmacokinetic
properties is driving extensive research effort in this field. Many structural modifications of …

Reactions between N-acyliminium ions and nucleophiles–also described as
amidoalkylation or Mannich type condensations–have been frequently utilized to introduce …

In this paper we describe the phosphine-catalyzed [3+ 2],[3+ 3],[4+ 3], and [3+ 2+ 3]
annulations of azomethine imines and allenoates. These processes mark the first use of …