TGFβ is a potent immune deviating agent, driving active forms of immune tolerance in
peripheral tissues through effects on the induction and resolution of inflammatory responses …

The epididymis is responsible for post-testicular sperm maturation, which consists in the
acquisition of forward motility and fertilizing ability. This organ is composed of three main …

Androgens are responsible for maintaining epididymal structure and functions. However,
little is known about how androgen action is mediated and the mechanisms underlying the …

Members of the transforming growth factor beta (TGFβ) family are pleiotropic cytokines with
key roles in tissue morphogenesis and growth. TGFβ1, TGFβ2 and TGFβ3 are abundant in …

Background: Oral contraceptive (OC) use is associated with a reduced risk of ovarian
cancer. An OC component, progestin, induces apoptosis in the primate ovarian epithelium …

There is a close functional relationship between the male reproductive and immune
systems. Immunological responses against sperm antigens or other elements of the …

The molecular and cellular control of embryonic testis development was investigated
through an analysis of the embryonic testis transcriptome to identify potential regulatory …

Background: Men and women are differently affected by coronary artery disease, suggesting
an important role of sex steroids. Moreover, testosterone (T) treatment is increasingly used in …

In 1926, pioneering studies by Benoit demonstrated that the epididymis is dependent on an
unknown testicular substance for maintenance of its structure and functions; the ratio of …

Androgen receptor-associated protein 55 (ARA55/Hic-5) belongs to the LIM protein
superfamily and is featured by three or four N-terminal LD motifs and four C-terminal zinc …