Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs,
targeted therapeutic drugs have become mainstream cancer treatments. Since the first …

Despite centuries since the discovery and study of cancer, cancer is still a lethal and
intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much …

The basis of immune evasion, a hallmark of cancer, can differ even when cancers arise from
one cell type such as in the human skin keratinocyte carcinomas: basal and squamous cell …

Introduction Medulloblastoma (MB) is a heterogeneous tumor of the cerebellum that is
divided into four main subgroups with distinct molecular and clinical features. Sonic …

Head and neck squamous cell carcinoma (HNSCC) is the sixth leading malignancy
worldwide, with a poor prognosis and limited treatment options. Molecularly targeted …

Surgical excision has been the preferred treatment for cutaneous malignancies, but can be
affected by various considerations. Noninvasive, self-administered topical treatments …

Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a high
mortality rate. It is regarded as a significant public health issue because of its complicated …

Targeting the hedgehog (HH) pathway to treat aggressive cancers of the brain, breast,
pancreas, and prostate has been ongoing for decades. Gli gene amplifications have been …

Opinion statement Advanced basal cell carcinoma (BCC) represents a small proportion of
BCCs that are not amenable to standard therapies due to lack of efficacy, high recurrence …

Gastrointestinal stromal tumor (GIST) is the most common sarcoma located in
gastrointestinal tract and derived from the interstitial cell of Cajal (ICC) lineage. Both ICC …