The realization that alterations in inhibitor of apoptosis (IAP) proteins are found in many
types of human cancer and are associated with chemoresistance, disease progression and …

Caspases, which are the executioners of apoptosis, comprise two distinct classes, the
initiators and the effectors. Although general structural features are shared between the …

The'inhibitor of apoptosis'(IAP) gene family, which was discovered less than a decade ago,
encodes a group of structurally related proteins that, in addition to their ability to suppress …

Establishing and maintaining homeostasis is critical to the well-being of an organism and is
determined by the balance of cell proliferation and death. Two genes that function together …

The number of cells in an organism is determined by regulating both cell proliferation and
cell death. Relatively few mechanisms have been identified that can modulate both of these …

Neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease trigger
neuronal cell death through endogenous suicide pathways. Surprisingly, although the cell …

Tissue growth during animal development is tightly controlled so that the organism can
develop harmoniously. The salvador (sav) gene, which encodes a scaffold protein, has been …

MicroRNAs (miRNAs) are small non-coding RNAs of about 18–24 nucleotides in length that
negatively regulate gene expression. Discovered only recently, it has become clear that they …

Caspases, a unique family of cysteine proteases, execute programmed cell death
(apoptosis). Caspases exist as inactive zymogens in cells and undergo a cascade of …

Far-red light regulates many aspects of seedling development, such as inhibition of
hypocotyl elongation and the promotion of greening, acting in part through phytochrome A …