Microglia and astrocytes play essential roles in the central nervous system contributing to
many functions including homeostasis, immune response, blood–brain barrier maintenance …

There is growing evidence that long-term central nervous system (CNS) inflammation
exacerbates secondary deterioration of brain structures and functions and is one of the …

Clearing amyloid-β (Aβ) through immunotherapy is one of the most promising therapeutic
approaches to Alzheimer's disease (AD). Although several monoclonal antibodies against …

Metabolic reprogramming is a hallmark of the immune cells in response to inflammatory
stimuli. This metabolic process involves a switch from oxidative phosphorylation (OXPHOS) …

Ferroptosis is implicated in a range of brain disorders, but it is unknown whether neurons or
glia in the brain are particularly effected. Here, we report that primary astrocytes (PA) …

The central nervous system (CNS) controls and regulates the functional activities of the
organ systems and maintains the unity between the body and the external environment. The …

The development of natural membranes as coatings for nanoparticles to traverse the blood-
brain barrier (BBB) presents an effective approach for treating central nervous system (CNS) …

Neuronal signalling is a key element in neuronal communication and is essential for the
proper functioning of the CNS. Astrocytes, the most prominent glia in the brain play a key …

Surgical trauma can induce an inflammatory response in the central nervous system.
Neuroinflammation is a crucial pathological mechanism of perioperative neurocognitive …

Progressive supranuclear palsy (PSP) is an incurable neurodegenerative disease
characterized by 4-repeat (0N/4R)-Tau protein accumulation in CNS neurons. We generated …