Theranostics: leveraging molecular imaging and therapy to impact patient management and secure the future of nuclear medicine
Nuclear medicine is experiencing a renaissance, with US Food and Drug Administration
approval recently being obtained for theranostic agents and a wide variety of such agents …
approval recently being obtained for theranostic agents and a wide variety of such agents …
SSTR2 in nasopharyngeal carcinoma: relationship with latent EBV infection and potential as a therapeutic target
Simple Summary Nasopharyngeal cancer (NPC) is a malignant epithelial tumor endemic to
parts of Asia and associated with infection by the Epstein–Barr virus (EBV) in these regions …
parts of Asia and associated with infection by the Epstein–Barr virus (EBV) in these regions …
High somatostatin receptor expression and efficacy of somatostatin analogues in patients with metastatic Merkel cell carcinoma
T Akaike, J Qazi, A Anderson, FS Behnia… - British Journal of …, 2021 - academic.oup.com
Background Merkel cell carcinoma (MCC) is an aggressive, high‐grade, cutaneous
neuroendocrine tumour (NET). Agents blocking programmed death 1/programmed death …
neuroendocrine tumour (NET). Agents blocking programmed death 1/programmed death …
Response to combined peptide receptor radionuclide therapy and checkpoint immunotherapy with Ipilimumab plus Nivolumab in metastatic Merkel cell carcinoma
J Ferdinandus, WP Fendler, K Lueckerath… - Journal of Nuclear …, 2022 - Soc Nuclear Med
For patients with Merkel cell carcinoma (MCC) who are refractory to immune checkpoint
inhibition (ICI), treatment options are limited. Few cases of MCCs have been reported to …
inhibition (ICI), treatment options are limited. Few cases of MCCs have been reported to …
Short-Interval, low-dose peptide receptor radionuclide therapy in combination with PD-1 checkpoint immunotherapy induces remission in immunocompromised …
A Aicher, A Sindrilaru, D Crisan, W Thaiss, J Steinacker… - Pharmaceutics, 2022 - mdpi.com
Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer of the elderly, with high
metastatic potential and poor prognosis. In particular, the primary resistance to immune …
metastatic potential and poor prognosis. In particular, the primary resistance to immune …
Combined targeted radiopharmaceutical therapy and immune checkpoint blockade: from preclinical advances to the clinic
MC Bellavia, RB Patel, CJ Anderson - Journal of Nuclear …, 2022 - Soc Nuclear Med
Immune checkpoint inhibitors (ICIs) have revolutionized cancer care, but many patients with
poorly immunogenic tumors fail to benefit. Preclinical studies have shown that external …
poorly immunogenic tumors fail to benefit. Preclinical studies have shown that external …
Peptide receptor radionuclide therapy in merkel cell carcinoma: a comprehensive review
Merkel cell carcinoma is a rare, aggressive skin malignancy, also known as neuroendocrine
carcinoma of the skin, with high rates of recurrence and distant metastasis. In refractory …
carcinoma of the skin, with high rates of recurrence and distant metastasis. In refractory …
Peptide receptor radionuclide therapy in neuroendocrine neoplasms and related tumors: from fundamentals to personalization and the newer experimental …
S Loharkar, S Basu - Expert Review of Precision Medicine and …, 2023 - Taylor & Francis
ABSTRACT Introduction Peptide Receptor Radionuclide Therapy (PRRT) is a type of
molecular-targeted endo-radionuclide therapy in which unsealed radiolabelled somatostatin …
molecular-targeted endo-radionuclide therapy in which unsealed radiolabelled somatostatin …
AAZTA5-squaramide ester competing with DOTA-, DTPA-and CHX-A ″-DTPA-analogues: Promising tool for 177Lu-labeling of monoclonal antibodies under mild …
Background Combining the advantages of both cyclic and acyclic chelator systems, AAZTA
(1, 4-bis (carboxymethyl)-6-[bis (carboxymethyl)] amino-6-methylperhydro-1, 4-diazepine) is …
(1, 4-bis (carboxymethyl)-6-[bis (carboxymethyl)] amino-6-methylperhydro-1, 4-diazepine) is …
Lanthanide conjugates as versatile instruments for therapy and diagnostics
C Herlan, S Bräse - Dalton Transactions, 2020 - pubs.rsc.org
Lanthanides have demonstrated outstanding properties in many fields of research including
biology and medicinal chemistry. Their unique luminescence and magnetic properties make …
biology and medicinal chemistry. Their unique luminescence and magnetic properties make …