Genomic and rapid effects of aldosterone: what we know and do not know thus far

MM Hermidorff, LVM de Assis, MC Isoldi - Heart failure reviews, 2017 - Springer
Aldosterone is the most known mineralocorticoid hormone synthesized by the adrenal
cortex. The genomic pathway displayed by aldosterone is attributed to the mineralocorticoid …

[HTML][HTML] The endocrinological component and signaling pathways associated to cardiac hypertrophy

APC Takano, N Senger… - Molecular and cellular …, 2020 - Elsevier
Although myocardial growth corresponds to an adaptive response to maintain cardiac
contractile function, the cardiac hypertrophy is a condition that occurs in many …

Aldosterone impairs mitochondrial function in human cardiac fibroblasts via A-kinase anchor protein 12

J Ibarrola, R Sadaba, E Martinez-Martinez… - Scientific reports, 2018 - nature.com
Aldosterone (Aldo) contributes to mitochondrial dysfunction and cardiac oxidative stress.
Using a proteomic approach, A-kinase anchor protein (AKAP)-12 has been identified as a …

Effect of alpha lipoic acid on in vitro development of bovine secondary preantral follicles

KMA Zoheir, GI Harisa, AA Allam, L Yang, X Li, A Liang… - Theriogenology, 2017 - Elsevier
The present study aimed to evaluate the in vitro effect of alpha lipoic acid (ALA) addition to
the culture medium on the development of the bovine secondary preantral follicles. Bovine …

How does pressure overload cause cardiac hypertrophy and dysfunction? High-ouabain affinity cardiac Na+ pumps are crucial

MP Blaustein - American Journal of Physiology-Heart and …, 2017 - journals.physiology.org
Left ventricular hypertrophy is frequently observed in hypertensive patients and is believed
to be due to the pressure overload and cardiomyocyte stretch. Three recent reports on mice …

Aldosterone synthase inhibitors for cardiorenal protection: ready for prime time?

A Mazzieri, F Timio, F Patera, F Trepiccione… - Kidney and Blood …, 2024 - karger.com
Background: Aldosterone is the principal mineralocorticoid hormone and the final effector of
the renin-angiotensin-aldosterone system. This hormone is primarily synthesized by the …

Rapid signalling responses via the G protein-coupled estrogen receptor, GPER, in a hippocampal cell line

PD Evans - Steroids, 2019 - Elsevier
The rapid non-genomic actions of 17β-estradiol in multiple tissues, including the nervous
system, may involve the activation of the G-protein-coupled receptor, GPER. Different …

[HTML][HTML] Aldosterone, STX and amyloid-β1-42 peptides modulate GPER (GPR30) signalling in an embryonic mouse hippocampal cell line (mHippoE-18)

PD Evans - Molecular and Cellular Endocrinology, 2019 - Elsevier
The GPCR, GPER, mediates many of the rapid, non-genomic actions of 17β-estradiol in
multiple tissues, including the nervous system. Controversially, it has also been suggested …

Extracellular matrix induced by steroids and aging through a G-protein-coupled receptor in a Drosophila model of renal fibrosis

W Zheng, K Ocorr, M Tatar - Disease models & mechanisms, 2020 - journals.biologists.com
Aldosterone is produced by the mammalian adrenal cortex to modulate blood pressure and
fluid balance; however, excessive, prolonged aldosterone promotes fibrosis and kidney …

Mineralocorticoid receptor antagonists lead to increased adenosine bioavailability and modulate contractile cardiac parameters

MM Hermidorff, LVM de Assis, JA Rodrigues… - Heart and Vessels, 2020 - Springer
Activation of mineralocorticoid receptor antagonists (MRAs) is cardioprotective; however,
this property is lost upon blockade or inactivation of adenosine (ADO) receptor A 2b. In this …