Toll-like receptors, associated biological roles, and signaling networks in non-mammals

L Nie, SY Cai, JZ Shao, J Chen - Frontiers in immunology, 2018 - frontiersin.org
The innate immune system is the first line of defense against pathogens, which is initiated by
the recognition of pathogen-associated molecular patterns (PAMPs) and endogenous …

Toll-like receptors (TLRs) in aquatic animals: signaling pathways, expressions and immune responses

PR Rauta, M Samanta, HR Dash, B Nayak, S Das - Immunology Letters, 2014 - Elsevier
The innate system's recognition of non-self and danger signals is mediated by a limited
number of germ-line encoded pattern recognition receptors (PRRs) that recognize pathogen …

Detecting Intestinal Goblet Cells of the Broadgilled Hagfish Eptatretus cirrhatus (Forster, 1801): A Confocal Microscopy Evaluation

A Alesci, S Pergolizzi, S Savoca, A Fumia, A Mangano… - Biology, 2022 - mdpi.com
Simple Summary The intestinal epithelium of fish, similar to mammals, consists mainly of
enterocytes and goblet cells. Goblet cells play a key role in the secretion of mucus, which, in …

Confocal characterization of intestinal dendritic cells from myxines to teleosts

A Alesci, G Capillo, A Fumia, E Messina, M Albano… - Biology, 2022 - mdpi.com
Simple Summary This research aimed to define intestinal DCs from myxines to teleosts by
using immunohistochemistry with TLR-2, Langerin/CD207, and MHC II. In particular, we …

[HTML][HTML] Expression and function of toll-like receptor 2 in vertebrate

S Pergolizzi, A Fumia, R D'Angelo, A Mangano… - Acta …, 2023 - Elsevier
Toll-like receptors (TLRs) are essential for identifying and detecting pathogen-associated
molecular patterns (PAMPs) produced by a variety of pathogens, including viruses and …

Intestinal immunity of dogfish Scyliorhinus canicula spiral valve: A histochemical, immunohistochemical and confocal study

ER Lauriano, S Pergolizzi, M Aragona… - Fish & Shellfish …, 2019 - Elsevier
The present study describes histochemical and immunohistochemical characteristics of the
spiral valve and its associated lymphoid tissue (GALT) in the dogfish Scyliorhinus canicula …

Riding the wave of innovation: immunoinformatics in fish disease control

SA Razali, MS Shamsir, NF Ishak, CF Low, WA Azemin - PeerJ, 2023 - peerj.com
The spread of infectious illnesses has been a significant factor restricting aquaculture
production. To maximise aquatic animal health, vaccination tactics are very successful and …

[HTML][HTML] Immune cells in the spiral intestine of Blackmouth catshark, Galeus melastomus: New insights into ancient gut defenders

G Bosi, BS Dezfuli, P Merella, L Giari - Egyptian Journal of Aquatic …, 2024 - Elsevier
This study aimed to describe the morphology and to characterize the immunohistochemistry
of the gut-associated lymphoid tissue (GALT) in the spiral intestine of the Blackmouth …

Identification and characterization of a novel Toll-like receptor 2 homologue in the large yellow croaker Larimichthys crocea

J Ao, Y Mu, K Wang, M Sun, X Wang, X Chen - Fish & Shellfish Immunology, 2016 - Elsevier
Toll-like receptors (TLRs) are key components of innate immunity that play significant roles
in immune defence against pathogen invasion. In the present study, we identified a novel …

Structurally diverse genes encode Tlr2 in rainbow trout: the conserved receptor cannot be stimulated by classical ligands to activate NF-κB in vitro

A Brietzke, M Arnemo, T Gjøen, H Rebl… - Developmental & …, 2016 - Elsevier
The mammalian toll-like receptor 2 (TLR2) is a dominant receptor for the recognition of Gram-
positive bacteria. Its structure and functional properties were unknown in salmonid fish. In …