In the mid-1980s, the identification of serine and threonine residues on nuclear and
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …

Post-translational modification with O-linked β-N-acetylglucosamine (O-GlcNAc), a process
referred to as O-GlcNAcylation, occurs on a vast variety of proteins. Mounting evidence in …

O-linked β-N-acetyl glucosamine (O-GlcNAc) is attached to proteins under glucose-replete
conditions; this posttranslational modification results in molecular and physiological …

The p75 neurotrophin receptor (p75 NTR) regulates a wide range of cellular functions,
including programmed cell death, axonal growth and degeneration, cell proliferation …

In the 30 years, since the discovery of nucleocytoplasmic glycosylation, O-GlcNAc has been
implicated in regulating cellular processes as diverse as protein folding, localization …

Activation of AMP-activated protein kinase (AMPK) in endothelial cells regulates energy
homeostasis, stress protection and angiogenesis, but the underlying mechanisms are …

Learning and memory deficits are early clinical manifestations of Huntington's disease (HD).
These cognitive impairments have been mainly associated with frontostriatal HD pathology; …

J. Neurochem.(2011) 117, 321–332. Abstract S100B is a soluble protein secreted by
astrocytes that exerts pro‐survival or pro‐apoptotic effects depending on the concentration …

The neurotrophin receptor p75NTR has been implicated in mediating neuronal apoptosis
after injury to the CNS. Despite its frequent induction in pathologic states, there is limited …

Neuroprotective therapies based on brain-derived neurotrophic factor (BDNF) administration
have been proposed for Huntington's disease (HD) treatment. However, our group has …