Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …

Presenilin-1 (PSEN1) has been verified as an important causative factor for early onset
Alzheimer's disease (EOAD). PSEN1 is a part of γ-secretase, and in addition to amyloid …

Alzheimer's Disease (AD) is a highly complex disease involving a broad range of clinical,
cellular, and biochemical manifestations that are currently not understood in combination …

Abstract Presenilin-1 (PS1) is the catalytic subunit of γ-secretase which cleaves within the
transmembrane domain of over 150 peptide substrates. Dominant missense mutations in …

Abstract γ-Secretase is an intramembrane aspartyl-protease catalyzing the final step in the
regulated intramembrane proteolysis of a large number of single-span type-1 …

γ-Secretase is an intramembrane-cleaving aspartyl protease that plays an essential role in
the processing of a variety of integral membrane proteins. Its role in the ultimate cleavage …

Alzheimer's disease manifests itself in brain tissue by neuronal death, due to aggregation of
β‐amyloid, produced by senile plaques, and hyperphosphorylation of the tau protein, which …

Membranes surrounding the biological cell and its internal compartments host proteins that
catalyze chemical reactions essential for the functioning of the cell. Rather than being a …

The intramembrane aspartyl protease γ-secretase (GSEC) cleaves single-span
transmembrane helices including the C-terminal fragment of the amyloid precursor protein …