The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

As angiogenesis was recognized as a core hallmark of cancer growth and survival, several
strategies have been implemented to target the tumour vasculature. Yet to date, attempts …

The extracellular matrix (ECM) is an abundant noncellular component of most solid tumors
known to support tumor progression and metastasis. The interplay between the ECM and …

Mortality from breast cancer is almost exclusively a result of tumor metastasis and resistance
to therapy and therefore understanding the underlying mechanisms is an urgent challenge …

The extracellular matrix (ECM) in the tumor microenvironment (TME) and upregulated
immune checkpoints (ICs) on antitumor immune cells impede the infiltration and killing effect …

Solid tumours comprise cancer cells that engage in continuous interactions with non-
malignant cells and with acellular components, forming the tumour microenvironment (TME) …

The biological complexity of cancer represents a tremendous clinical challenge, resulting in
the frequent failure of current treatment protocols. In the rapidly evolving scenario of a …

The 3D architecture of tissues bearing tumors impacts on the mechanical microenvironment
of cancer, the accessibility of stromal cells, and the routes of invasion. A myriad of intrinsic …

The tumor physical microenvironment (TPME) contributes to cancer chemoresistance in both
mechanical and mechanobiological approaches. Along with chemotherapy, the tumor …

High-grade serous ovarian cancer (HGSOC) is notoriously known as the “silent killer” of post-
menopausal women as it has an insidious progression and is the deadliest gynaecological …