Randomized clinical trials demonstrated that CDK4/6 inhibitors are highly effective in
patients with hormone receptor-positive (HR+), HER2-negative (HER2-) metastatic breast …

The non-receptor tyrosine kinase Fyn-related kinase (FRK) is a member of the BRK family
kinases (BFKs) and is distantly related to the Src family kinases (SFKs). FRK was first …

Whole transcriptome studies typically yield large amounts of data, with expression values for
all genes or transcripts of the genome. The search for genes of interest in a particular study …

Breast cancer is a serious health issue and a major concern in biomedical research.
Alteration in major signaling (viz. PI3K-AKT-mTOR, Ras-Raf-MEK-Erk, NF-kB, cyclin D1, JAK …

Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide due to
metastasis. Paraspeckle component 1 (PSPC1) upregulation has been identified as an HCC …

Colorectal cancer is a common malignant tumor of the digestive tract. Despite advances in
diagnostic techniques and medications. Its prognosis remains challenging. DNA methylation …

Objective: Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease in
the world, and its pathogenesis is not fully understood. Disulfidptosis is the most recently …

Abstract Protein tyrosine kinase 6 (PTK6; also called Brk) is overexpressed in 86% of
patients with breast cancer; high PTK6 expression predicts poor outcome. We reported …

Simple Summary Protein tyrosine kinases (PTKs) are classified into two groups: one group
includes tyrosine kinases, and the second group includes serine/threonine kinases. The …

Background BRK is, a non-receptor tyrosine kinase, overexpressed in approximately 85% of
human invasive ductal breast tumors. It is not clear whether BRK expression correlates with …