Klotho is a single-pass transmembrane protein highly expressed in the kidney. Membrane
Klotho protein acts as a co-receptor for fibroblast growth factor-23. Its extracellular domain is …

While sodium is essential for human homeostasis, current salt consumption far exceeds
physiological needs. Strong evidence suggests a direct causal relationship between sodium …

Background It is known that some people age faster than others, some people live into old
age disease-free, while others develop age-related chronic diseases. With a rapidly aging …

The three-spined stickleback (Gasterosteus aculeatus) represents a convenient model to
study microevolution—adaptation to a freshwater environment. Although genetic …

Soluble Klotho (sKl) in the circulation can be generated directly by alterative splicing of the
Klotho transcript or the extracellular domain of membrane Klotho can be released from …

Most normal human cells have a finite replicative capacity and eventually undergo cellular
senescence, whereby cells cease to proliferate. Cellular senescence is also induced by …

Hypercoagulability increases risk of thrombi that cause cardiovascular events. Here we
identify plasma sodium concentration as a factor that modulates blood coagulability by …

Body water balance is determined by fundamental homeostatic mechanisms that maintain
stable volume, osmolality and the composition of extracellular and intracellular fluids. Water …

Cardiovascular diseases (CVDs) are a leading health problem worldwide. Epidemiologic
studies link high salt intake and conditions predisposing to dehydration such as low water …

The young African turquoise killifish has a high regenerative capacity, but loses it with
advancing age, adopting several aspects of the limited form of mammalian regeneration. We …