Unsupervised machine learning for exploratory data analysis in imaging mass spectrometry

N Verbeeck, RM Caprioli… - Mass spectrometry …, 2020 - Wiley Online Library
Imaging mass spectrometry (IMS) is a rapidly advancing molecular imaging modality that
can map the spatial distribution of molecules with high chemical specificity. IMS does not …

[HTML][HTML] MALDI Imaging mass spectrometry: current frontiers and perspectives in pathology research and practice

M Aichler, A Walch - Laboratory investigation, 2015 - Elsevier
MALDI Imaging mass spectrometry has entered the field of tissue-based research by
providing unique advantages for analyzing tissue specimen in an unprecedented detail. A …

Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research

JL Norris, RM Caprioli - Chemical reviews, 2013 - ACS Publications
Human beings are adept at discerning relevant information from complex systems by
processing visual information. Similarly, as scientists labor to understand the fundamental …

[HTML][HTML] Identification and characterization of post-translational modifications: Clinical implications

J Hermann, L Schurgers, V Jankowski - Molecular aspects of medicine, 2022 - Elsevier
Post-translational modifications (PTMs) generate marginally modified isoforms of native
peptides, proteins and lipoproteins thereby regulating protein functions, molecular …

Mass spectrometry imaging for clinical research–latest developments, applications, and current limitations

PM Vaysse, RMA Heeren, T Porta, B Balluff - Analyst, 2017 - pubs.rsc.org
Mass spectrometry is being used in many clinical research areas ranging from toxicology to
personalized medicine. Of all the mass spectrometry techniques, mass spectrometry …

Sample preparation for mass spectrometry imaging: small mistakes can lead to big consequences

RJA Goodwin - Journal of proteomics, 2012 - Elsevier
Mass spectrometry imaging (MSI) enables the direct analysis of molecules from the surface
of a wide variety of samples, allowing the multiplex measurement of both abundance and …

Machine learning methods for microbiome studies

J Namkung - Journal of Microbiology, 2020 - Springer
Researches on the microbiome have been actively conducted worldwide and the results
have shown human gut bacterial environment significantly impacts on immune system …

MALDI TOF imaging mass spectrometry in clinical pathology: a valuable tool for cancer diagnostics

J Kriegsmann, M Kriegsmann… - … journal of oncology, 2014 - spandidos-publications.com
Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) imaging mass
spectrometry (IMS) is an evolving technique in cancer diagnostics and combines the …

Matrix-assisted laser desorption ionization imaging mass spectrometry: in situ molecular mapping

PM Angel, RM Caprioli - Biochemistry, 2013 - ACS Publications
Matrix-assisted laser desorption ionization imaging mass spectrometry (IMS) is a relatively
new imaging modality that allows mapping of a wide range of biomolecules within a thin …

MALDI‐imaging for classification of epithelial ovarian cancer histotypes from a tissue microarray using machine learning methods

O Klein, F Kanter, H Kulbe, P Jank… - PROTEOMICS …, 2019 - Wiley Online Library
Purpose Precise histological classification of epithelial ovarian cancer (EOC) has immanent
diagnostic and therapeutic consequences, but remains challenging in histological routine …