Immune checkpoint inhibition for pancreatic ductal adenocarcinoma: current limitations and future options

D Kabacaoglu, KJ Ciecielski, DA Ruess… - Frontiers in …, 2018 - frontiersin.org
Pancreatic ductal adenocarcinoma (PDAC), as the most frequent form of pancreatic
malignancy, still is associated with a dismal prognosis. Due to its late detection, most …

The roles of CCR9/CCL25 in inflammation and inflammation-associated diseases

X Wu, M Sun, Z Yang, C Lu, Q Wang… - Frontiers in cell and …, 2021 - frontiersin.org
Chemokine is a structure-related protein with a relatively small molecular weight, which can
target cells to chemotaxis and promote inflammatory response. Inflammation plays an …

The effector program of human CD8 T cells supports tissue remodeling

M Delacher, L Schmidleithner, M Simon… - Journal of Experimental …, 2024 - rupress.org
CD8 T lymphocytes are classically viewed as cytotoxic T cells. Whether human CD8 T cells
can, in parallel, induce a tissue regeneration program is poorly understood. Here, antigen …

From biomarkers to therapeutic targets—the promises and perils of long non-coding RNAs in cancer

T Gutschner, G Richtig, M Haemmerle… - Cancer and Metastasis …, 2018 - Springer
Biomarker-driven personalized cancer therapy is a field of growing interest, and several
molecular tests have been developed to detect biomarkers that predict, eg, response of …

[HTML][HTML] Microfluidic single-cell technology in immunology and antibody screening

YFS Seah, H Hu, CA Merten - Molecular aspects of medicine, 2018 - Elsevier
Single-cell technology has a major impact on the field of immunology. It enables the kinetics
and logic of immune signaling and immune cell migration to be elucidated, facilitates …

Integrating immunology and microfluidics for single immune cell analysis

N Sinha, N Subedi, J Tel - Frontiers in immunology, 2018 - frontiersin.org
The field of immunoengineering aims to develop novel therapies and modern vaccines to
manipulate and modulate the immune system and applies innovative technologies toward …

Re-education of the tumor microenvironment with targeted therapies and immunotherapies

SF Ngiow, A Young - Frontiers in immunology, 2020 - frontiersin.org
The clinical success of cancer immunotherapies targeting PD-1 and CTLA-4 has ignited a
substantial research effort to improve our understanding of tumor immunity. Recent studies …

CCR9 in cancer: oncogenic role and therapeutic targeting

Z Tu, R Xiao, J Xiong, KM Tembo, X Deng… - Journal of hematology & …, 2016 - Springer
Cancer is currently one of the leading causes of death worldwide and is one of the most
challenging major public health problems. The main challenges faced by clinicians in the …

Signals controlling lytic granule polarization at the cytotoxic immune synapse

A Kabanova, V Zurli, CT Baldari - Frontiers in immunology, 2018 - frontiersin.org
Cytotoxic immunity relies on specialized effector T cells, the cytotoxic T cells, which are
endowed with specialized cytolytic machinery that permits them to induce death of their …

CCR9 and CCL25: A review of their roles in tumor promotion

B Xu, C Deng, X Wu, T Ji, L Zhao, Y Han… - Journal of cellular …, 2020 - Wiley Online Library
Chemokines constitute a superfamily of small chemotactic cytokines with functions that are
based on interactions with their corresponding receptors. It has been found that, among …