Vancomycin is the best-known of the glycopeptide group antibiotics (GPAs), a family of
agents which operate by binding the C-terminal deptide D-Ala–D-Ala. This anionic epitope …

Protein-catalyzed capture agents (PCCs) are synthetic and modular peptide-based affinity
agents that are developed through the use of single-generation in situ click chemistry …

Alpha helices form a critical part of the binding interface for many protein–protein
interactions, and chemically stabilized synthetic helical peptides can be effective inhibitors of …

Solid phase screenings of one bead one compound (OBOC) libraries have been widely
used to find ligands with pharmacological and analytical uses, and to purify or detect …

The identification of initial hits is a crucial stage in the drug discovery process. Although
many projects adopt high-throughput screening of small-molecule libraries at this stage …

Cyclic peptides, owing to their good stability, high resistance to exo-and to some extent endo-
peptidases, enhanced binding affinity and selectivity towards target biomolecules, are …

Chapter 1 2 mechanisms and peptide drug delivery, including cell permeability to prosecute
intracellular targets, is re-defining the term “druggability”. Beyond such convergent …

Phosphorylation is a key process for changing the activity and function of proteins. The
impact of phospho-serine (pSer),-threonine (pThr) and-tyrosine (pTyr) is certainly …

Small molecule probe development is pivotal in biomolecular science. Research described
here was undertaken to develop a non‐peptidic chemotype, piptides, that is amenable to …

Short cyclic peptides have a great interest in therapeutic, diagnostic and affinity
chromatography applications. The screening of 'one‐bead‐one‐peptide'combinatorial …