Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis

T Olsson, LF Barcellos, L Alfredsson - Nature Reviews Neurology, 2017 - nature.com
Genetic predisposition to multiple sclerosis (MS) only explains a fraction of the disease risk;
lifestyle and environmental factors are key contributors to the risk of MS. Importantly, these …

Environmental and genetic risk factors for MS: an integrated review

E Waubant, R Lucas, E Mowry, J Graves… - Annals of clinical …, 2019 - Wiley Online Library
Recent findings have provided a molecular basis for the combined contributions of
multifaceted risk factors for the onset of multiple sclerosis (MS). MS appears to start as a …

Emerging role of air pollution in autoimmune diseases

CN Zhao, Z Xu, GC Wu, YM Mao, LN Liu, YL Dan… - Autoimmunity …, 2019 - Elsevier
Autoimmune diseases (ADs) are a broad spectrum of disorders featured by the body's
immune responses being directed against its own tissues, resulting in prolonged …

Lifestyle and environmental factors in multiple sclerosis

L Alfredsson, T Olsson - Cold Spring …, 2019 - perspectivesinmedicine.cshlp.org
Lifestyle and environmental factors potently influence the risk of multiple sclerosis (MS),
because genetic predisposition only explains a fraction of the risk increase. There is strong …

Airborne particulate matter: human exposure and health effects

JE Thompson - Journal of occupational and environmental …, 2018 - journals.lww.com
Objective: Exposure to airborne particulate matter (PM) is estimated to cause millions of
premature deaths annually. This work conveys known routes of exposure to PM and …

Outdoor ambient air pollution and neurodegenerative diseases: the neuroinflammation hypothesis

RL Jayaraj, EA Rodriguez, Y Wang… - Current environmental …, 2017 - Springer
Abstract Purpose of Review Accumulating research indicates that ambient outdoor air
pollution impacts the brain and may affect neurodegenerative diseases, yet the potential …

Air pollution, a rising environmental risk factor for cognition, neuroinflammation and neurodegeneration: The clinical impact on children and beyond

L Calderón-Garcidueñas, E Leray, P Heydarpour… - Revue …, 2016 - Elsevier
Air pollution (indoors and outdoors) is a major issue in public health as epidemiological
studies have highlighted its numerous detrimental health consequences (notably …

A review of epidemiological research on adverse neurological effects of exposure to ambient air pollution

X Xu, SU Ha, R Basnet - Frontiers in public health, 2016 - frontiersin.org
There is a growing body of epidemiological research reporting the neurological effects of
ambient air pollution. We examined current evidence, identified the strengths and …

The air we breathe: air pollution as a prevalent proinflammatory stimulus contributing to neurodegeneration

M Jankowska-Kieltyka, A Roman… - Frontiers in Cellular …, 2021 - frontiersin.org
Air pollution is regarded as an important risk factor for many diseases that affect a large
proportion of the human population. To date, accumulating reports have noted that …

Toxicity of inhaled particulate matter on the central nervous system: neuroinflammation, neuropsychological effects and neurodegenerative disease

Y Wang, L Xiong, M Tang - Journal of Applied Toxicology, 2017 - Wiley Online Library
Particulate matter (PM) combined with meteorological factors cause the haze, which brings
inconvenience to people's daily life and deeply endanger people's health. Accumulating …