Our previous International Union of Basic and Clinical Pharmacology report on the
nomenclature and classification of adenosine receptors (2011) contained a number of …

Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …

Unpredictable chronic mild stress (UCMS) is one of the most commonly used, robust and
translatable models for studying the neurobiological basis of major depression. Although the …

Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

Nowadays, caffeine is one of the most commonly consumed substances, which presents in
many plants and products. It has both positive and negative effects on the human body, and …

After more than two decades of preclinical and clinical studies, on August 27, 2019, the US
Food and Drug Administration (FDA) approved the adenosine A 2A receptor antagonist …

Many plants, including some of the commonly consumed herbs and spices in our daily food,
can be safely and effectively used to prevent and/or treat some health concerns. For …

The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …

INTRODUCTION Astrocytes support neuronal function throughout the central nervous
system. In the gray matter, they regulate synapse number during development, remove …

Caffeine is the most widely used psychostimulant in Western countries, with antioxidant, anti‐
inflammatory and anti‐apoptotic properties. In Alzheimer's disease (AD), caffeine is …