Synthetic cells: from simple bio‐inspired modules to sophisticated integrated systems

C Guindani, LC da Silva, S Cao, T Ivanov… - Angewandte …, 2022 - Wiley Online Library
Bottom‐up synthetic biology is the science of building systems that mimic the structure and
function of living cells from scratch. To do this, researchers combine tools from chemistry …

Bioinspired polymer vesicles and membranes for biological and medical applications

CG Palivan, R Goers, A Najer, X Zhang, A Car… - Chemical society …, 2016 - pubs.rsc.org
Biological membranes play an essential role in living organisms by providing stable and
functional compartments, preserving cell architecture, whilst supporting signalling and …

Getting around the cell: physical transport in the intracellular world

SS Mogre, AI Brown, EF Koslover - Physical Biology, 2020 - iopscience.iop.org
Eukaryotic cells face the challenging task of transporting a variety of particles through the
complex intracellular milieu in order to deliver, distribute, and mix the many components that …

Achieving high permeability and enhanced selectivity for Angstrom-scale separations using artificial water channel membranes

Y Shen, W Song, DR Barden, T Ren, C Lang… - Nature …, 2018 - nature.com
Synthetic polymer membranes, critical to diverse energy-efficient separations, are subject to
permeability-selectivity trade-offs that decrease their overall efficacy. These trade-offs are …

Multifunctional biomedical materials derived from biological membranes

Y Wang, X Xu, X Chen, J Li - Advanced Materials, 2022 - Wiley Online Library
The delicate structure and fantastic functions of biological membranes are the successful
evolutionary results of a long‐term natural selection process. Their excellent biocompatibility …

[HTML][HTML] Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment

T Einfalt, D Witzigmann, C Edlinger, S Sieber… - Nature …, 2018 - nature.com
Despite tremendous efforts to develop stimuli-responsive enzyme delivery systems, their
efficacy has been mostly limited to in vitro applications. Here we introduce, by using an …

Polymeric Giant Unilamellar Vesicles with Integrated DNA‐Origami Nanopores: An Efficient Platform for Tuning Bioreaction Dynamics Through Controlled Molecular …

R Cochereau, V Maffeis, EC Dos Santos… - Advanced Functional …, 2023 - Wiley Online Library
Giant unilamellar vesicles (GUVs) are microcompartments serving to confine reactions,
allow signaling pathways, or design synthetic cells. Polymer GUVs are composed of …

Biocatalysis in polymersomes: improving multienzyme cascades with incompatible reaction steps by compartmentalization

L Klermund, ST Poschenrieder, K Castiglione - Acs Catalysis, 2017 - ACS Publications
Incompatibilities encountered in multienzyme syntheses often arise from inhibition or
inactivation of individual enzymes by low-molecular-mass compounds. Polymersomes have …

Interface engineering in multiphase systems toward synthetic cells and organelles: From soft matter fundamentals to biomedical applications

Z Liu, W Zhou, C Qi, T Kong - Advanced Materials, 2020 - Wiley Online Library
Synthetic cells have a major role in gaining insight into the complex biological processes of
living cells; they also give rise to a range of emerging applications from gene delivery to …

Polymer capsules as micro-/nanoreactors for therapeutic applications: Current strategies to control membrane permeability

A Larrañaga, M Lomora, JR Sarasua… - Progress in Materials …, 2017 - Elsevier
Polymer capsules, fabricated either with the aid of a sacrificial template or via the self-
assembly of block copolymers into polymer vesicles (polymersomes), have attracted a great …