Gonadal development is the first step in human reproduction. Aberrant gonadal
development during the fetal period is a major cause of disorders/differences of sex …

Abstract NR2F2 encodes COUP-TFII, an orphan nuclear receptor required for the
development of the steroidogenic lineages of the murine fetal testes and ovaries …

In mammals, gonadal somatic cell lineage differentiation determines the development of the
bipotential gonad into either the ovary or testis. Sertoli cells, the only somatic cells in the …

Background The absence of expression of the Y-chromosome linked testis-determining
gene SRY in early supporting gonadal cells (ESGC) leads bipotential gonads into ovarian …

Leydig cells are essential components of testicular interstitial tissue and serve as a primary
source of androgen in males. A functional deficiency in Leydig cells often causes severe …

Today, the studies are limited on roles of insulin-like peptide 3 (INSL3), insulin-like peptide 7
(INSL7), and relaxin family peptide receptor 1 (RXFP1) which are synthesized by the testis. It …

The peptide hormone insulin-like 3 (INSL3) is produced almost exclusively by Leydig cells of
the male gonad. INSL3 has several functions such as fetal testis descent and bone …

Background Leydig cells produce testosterone and insulin‐like 3, two hormones essential
for male sex differentiation and reproductive function. The orphan nuclear receptor, chicken …

Male genital development in XY mammalian fetuses is triggered by the action of hormones,
including testosterone, secreted by the developing testes. Defects in this process are a …