The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …

Streptococcus pyogenes, also known as group A Streptococcus (GAS), causes mild human
infections such as pharyngitis and impetigo and serious infections such as necrotizing …

Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

Group A streptococci are model extracellular gram-positive pathogens responsible for
pharyngitis, impetigo, rheumatic fever, and acute glomerulonephritis. A resurgence of …

Many important interactions between bacterial pathogens and their hosts are highly specific
binding events that involve host or pathogen carbohydrate structures (glycans). Glycan …

Hyaluronic acid (HA) is a glycosaminoglycan widely distributed in the human body,
especially in body fluids and the extracellular matrix of tissues. It plays a crucial role not only …

The cell wall envelope of gram-positive bacteria is a macromolecular, exoskeletal organelle
that is assembled and turned over at designated sites. The cell wall also functions as a …

Streptococcus pyogenes is also known as group A Streptococcus (GAS) and is an important
human pathogen that causes considerable morbidity and mortality worldwide. The GAS …

The increasing prevalence of antibiotic-resistant bacteria portends an impending
postantibiotic age, characterized by diminishing efficacy of common antibiotics and routine …

Currently, the bacterial resistance, especially to most commonly used antibiotics has proved
to be a severe therapeutic problem. Nosocomial and community-acquired infections are …