PARP and PARG inhibitors in cancer treatment
D Slade - Genes & development, 2020 - genesdev.cshlp.org
Oxidative and replication stress underlie genomic instability of cancer cells. Amplifying
genomic instability through radiotherapy and chemotherapy has been a powerful but …
genomic instability through radiotherapy and chemotherapy has been a powerful but …
[HTML][HTML] A decade of clinical development of PARP inhibitors in perspective
Genomic instability is a hallmark of cancer, and often is the result of altered DNA repair
capacities in tumour cells. DNA damage repair defects are common in different cancer types; …
capacities in tumour cells. DNA damage repair defects are common in different cancer types; …
Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency
Mutations in BRCA1 or BRCA2 (BRCA) is synthetic lethal with poly (ADP-ribose)
polymerase inhibitors (PARPi). Lethality is thought to derive from DNA double-stranded …
polymerase inhibitors (PARPi). Lethality is thought to derive from DNA double-stranded …
Mechanisms of PARP inhibitor sensitivity and resistance
AD D'Andrea - DNA repair, 2018 - Elsevier
BRCA1 and BRCA2 deficient tumor cells are sensitive to inhibitors of Poly ADP Ribose
Polymerase (PARP1) through the mechanism of synthetic lethality. Several PARP inhibitors …
Polymerase (PARP1) through the mechanism of synthetic lethality. Several PARP inhibitors …
Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models
Ovarian cancer (OVCA) inevitably acquires resistance to platinum chemotherapy and PARP
inhibitors (PARPi). We show that acquisition of PARPi-resistance is accompanied by …
inhibitors (PARPi). We show that acquisition of PARPi-resistance is accompanied by …
Replication stress and cancer
Genome instability is a hallmark of cancer, and DNA replication is the most vulnerable
cellular process that can lead to it. Any condition leading to high levels of DNA damage will …
cellular process that can lead to it. Any condition leading to high levels of DNA damage will …
Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins
Homologous recombination (HR) is a major pathway for the repair of DNA double-strand
breaks in mammalian cells, the defining step of which is homologous strand exchange …
breaks in mammalian cells, the defining step of which is homologous strand exchange …
[HTML][HTML] BRCA genes: the role in genome stability, cancer stemness and therapy resistance
I Gorodetska, I Kozeretska, A Dubrovska - Journal of Cancer, 2019 - ncbi.nlm.nih.gov
Carcinogenesis is a multistep process, and tumors frequently harbor multiple mutations
regulating genome integrity, cell division and death. The integrity of cellular genome is …
regulating genome integrity, cell division and death. The integrity of cellular genome is …
A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2
K Schlacher, H Wu, M Jasin - Cancer cell, 2012 - cell.com
Genes mutated in patients with Fanconi anemia (FA) interact with the DNA repair genes
BRCA1 and BRCA2/FANCD1 to suppress tumorigenesis, but the molecular functions …
BRCA1 and BRCA2/FANCD1 to suppress tumorigenesis, but the molecular functions …
Transcription-mediated replication hindrance: a major driver of genome instability
B Gómez-González, A Aguilera - Genes & development, 2019 - genesdev.cshlp.org
Genome replication involves dealing with obstacles that can result from DNA damage but
also from chromatin alterations, topological stress, tightly bound proteins or non-B DNA …
also from chromatin alterations, topological stress, tightly bound proteins or non-B DNA …