The concerted interaction of genetic and environmental factors acts on the preterm human
immature lung with inflammation being the common denominator leading to the …

Over the past three decades, advances in prenatal and neonatal intensive care have
contributed to marked improvements in survival rates for extremely immature infants born …

Objectives: Although there are similarities in the pathophysiology of acute respiratory
distress syndrome in adults and children, pediatric-specific practice patterns, comorbidities …

Objective: Tidal volume (VT) and volume of gas caused by positive end-expiratory pressure
(V PEEP) generate dynamic and static lung strains, respectively. Our aim was to clarify …

Rationale: Premature infants are exposed to potentially injurious ventilation in the delivery
room. Assessments of lung injury are confounded by effects of subsequent ventilatory …

It is well established that mechanical ventilation can injure the lung, producing an entity
known as ventilator-induced lung injury (VILI). There are various forms of VILI, including …

Rationale: Many authors have suggested that the mechanism by which atelectasis
contributes to injury is through the repetitive opening and closing of distal airways in lung …

Rationale: In patients with severe, acute respiratory failure undergoing venovenous
extracorporeal membrane oxygenation (VV-ECMO), the optimal strategy for mechanical …

Bronchopulmonary dysplasia (BPD) is a unique injury syndrome caused by prolonged injury
and repair imposed on an immature and developing lung. The decreased septation and …

Bronchopulmonary dysplasia (BPD) frequently complicates preterm birth and leads to
significant long-term morbidity. Unfortunately, few therapies are known to effectively prevent …