Loss of functional β-cell mass is the key mechanism leading to the two main forms of
diabetes mellitus—type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) …

Diabetes is a chronic metabolic disorder characterized by inappropriately elevated glucose
levels as a result of impaired pancreatic β cell function and insulin resistance. Extensive …

The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

Islets of Langerhans are islands of endocrine cells scattered throughout the pancreas. A
number of new studies have pointed to the potential for conversion of non-β islet cells in to …

Significance: Metabolic syndrome is a frequent precursor of type 2 diabetes mellitus (T2D), a
disease that currently affects∼ 8% of the adult population worldwide. Pancreatic beta-cell …

Context: Diabetes is associated with a deficit of insulin-producing β-cells. Animal studies
show that β-cells become dedifferentiated in diabetes, reverting to a progenitor-like stage …

Imeglimin is an investigational first‐in‐class novel oral agent for the treatment of type 2
diabetes (T2D). Several pivotal phase III trials have been completed with evidence of …

Beta cell dysfunction and insulin resistance are inherently complex with their interrelation for
triggering the pathogenesis of diabetes also somewhat undefined. Both pathogenic states …

Among the most widely used animal models in obesity-induced type 2 diabetes mellitus
(T2DM) research are the congenital leptin-and leptin receptor-deficient rodent models …

Diabetes is a major global problem. During the past decade, the genetic basis of various
monogenic forms of the disease, and their underlying molecular mechanisms, have been …