▪ Abstract We review the physical properties of phosphatidylinositol 4, 5-bisphosphate (PIP2)
that determine both its specific interactions with protein domains of known structure and its …

▪ Abstract Research in the past decade has revealed that many cytosolic proteins are
recruited to different cellular membranes to form protein-protein and lipid-protein interactions …

Polyphosphoinositides are an important class of lipid that recruit specific effector proteins to
organelle membranes. One member, phosphatidylinositol 4-phosphate (PtdIns4 P) has …

Polyphosphoinositides (PPIn) are an important family of phospholipids located on the
cytoplasmic leaflet of eukaryotic cell membranes. Collectively, they are critical for the …

▪ Abstract Phosphoinositides [PPIs, which collectively refer to phosphorylated derivatives of
phosphatidylinositol (PI)] have a pivotal role as precursors to important second messengers …

Phosphoinositides play a crucial role in regulating many cellular functions, such as actin
dynamics, signaling, intracellular trafficking, membrane dynamics, and cell–matrix adhesion …

Pleckstrin homology (PH) domains are small protein modules known for their ability to bind
phosphoinositides and to drive membrane recruitment of their host proteins. We investigated …

Phosphatidylinositol 4, 5-biphosphate (PI [4, 5] P2) has emerged as an important signaling
molecule in the membrane for regulating vesicle exo-and endocytosis and the …

The membranes of eukaryotic cells create hydrophobic barriers that control substance and
information exchange between the inside and outside of cells and between cellular …

Class I phosphoinositide 3-OH kinase (PI3K) signaling is central to animal growth and
metabolism, and pathological disruption of this pathway affects cancer and diabetes …