Simple Summary Gastric adenocarcinoma is the fifth most common cancer worldwide and
the fourth most lethal. It is often asymptomatic at an early stage, when survival rates are …

Although immunotherapy has revolutionized solid tumor treatment, durable responses in
gastric cancer (GC) remain limited. The heterogeneous tumor microenvironment (TME) …

Streptococcus anginosus (S. anginosus) was enriched in the gastric mucosa of patients with
gastric cancer (GC). Here, we show that S. anginosus colonized the mouse stomach and …

Unravelling the origin and evolution of precancerous lesions is crucial for effectively
preventing malignant transformation, yet our current knowledge remains limited 1, 2, 3. Here …

Background Organoids are approved by the US FDA as an alternative to animal
experiments to guide drug development and for sensitivity screening. Stable organoids …

Aging is a multifaceted process influenced by hereditary factors, lifestyle, and environmental
elements. As time progresses, the human body experiences degenerative changes in major …

Gastric cancer (GC) is a highly heterogeneous disease with a complex tumor
microenvironment (TME) that encompasses multiple cell types including cancer cells …

Background & Aims Gastric metaplasia may arise as a consequence of chronic inflammation
and is associated with an increased risk of gastric cancer development. Although …

Early detection and intervention of cancer or precancerous lesions hold great promise to
improve patient survival. However, the processes of cancer initiation and the normal …

Background The purpose of the study was to conduct a comprehensive genomic
characterization of gene alterations, microsatellite instability (MSI), and tumor mutational …