Ultrasound‐mediated nano‐sized drug delivery systems for cancer treatment: Multi‐scale and multi‐physics computational modeling
F Moradi Kashkooli, TK Hornsby… - Wiley …, 2024 - Wiley Online Library
Computational modeling enables researchers to study and understand various complex
biological phenomena in anticancer drug delivery systems (DDSs), especially nano‐sized …
biological phenomena in anticancer drug delivery systems (DDSs), especially nano‐sized …
Theranostic digital twins: Concept, framework and roadmap towards personalized radiopharmaceutical therapies
Radiopharmaceutical therapy (RPT) is a rapidly developing field of nuclear medicine, with
several RPTs already well established in the treatment of several different types of cancers …
several RPTs already well established in the treatment of several different types of cancers …
Stimuli-sensitive nano-drug delivery with programmable size changes to enhance accumulation of therapeutic agents in tumors
Nano-based drug delivery systems hold significant promise for cancer therapies. Presently,
the poor accumulation of drug-carrying nanoparticles in tumors has limited their success. In …
the poor accumulation of drug-carrying nanoparticles in tumors has limited their success. In …
Spatiotemporal multi-scale modeling of radiopharmaceutical distributions in vascularized solid tumors
We present comprehensive mathematical modeling of radiopharmaceutical spatiotemporal
distributions within vascularized solid tumors. The novelty of the presented model is at …
distributions within vascularized solid tumors. The novelty of the presented model is at …
Spatiotemporal modeling of radiopharmaceutical transport in solid tumors: Application to 177Lu-PSMA therapy of prostate cancer
Background and objective 177 Lu-labeled prostate-specific membrane antigen (PSMA)
radiopharmaceutical therapy (RPT) represents a pivotal advancement in addressing …
radiopharmaceutical therapy (RPT) represents a pivotal advancement in addressing …
Targeted nano-sized drug delivery to heterogeneous solid tumor microvasculatures: Implications for immunoliposomes exhibiting bystander killing effect
Targeted drug delivery to cancer cells utilizing antibodies against oncogenic cell-surface
receptors is an emerging therapeutical approach. Here, we developed a computational …
receptors is an emerging therapeutical approach. Here, we developed a computational …
[HTML][HTML] Numerical evaluation of heat-triggered drug release via thermo-sensitive liposomes: A comparison between image-based vascularized tumor and volume …
In this study, two numerical models for controlled drug delivery through thermo-sensitive
liposomes under mild microwave hyperthermia are compared. The first model simulates …
liposomes under mild microwave hyperthermia are compared. The first model simulates …
Synthetic 18F-FDG PET image generation using a combination of biomathematical modeling and machine learning
Simple Summary Training computer-assisted algorithms on medical images, particularly 18F-
fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) due to its excellent …
fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) due to its excellent …
[HTML][HTML] Localized radiotherapy of solid tumors using radiopharmaceutical loaded implantable system: insights from a mathematical model
Introduction Computational models yield valuable insights into biological interactions not
fully elucidated by experimental approaches. This study investigates an innovative …
fully elucidated by experimental approaches. This study investigates an innovative …
Mitochondrial UQCC3 controls embryonic and tumor angiogenesis by regulating VEGF expression
G Zhang, B Liu, Y Yang, S Xie, L Chen, H Luo, J Zhong… - Iscience, 2023 - cell.com
Mitochondria play important roles in angiogenesis. However, the mechanisms remain
elusive. In this study, we found that mitochondrial ubiquinol-cytochrome c reductase …
elusive. In this study, we found that mitochondrial ubiquinol-cytochrome c reductase …