Background: Infections caused by multi-drug-resistant Gram-negative bacteria, particularly
Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae, that …

Background Nephrotoxicity and neurotoxicity are commonly associated with polymyxin
treatment; however, the emergence of multidrug-resistant Gram-negative bacteria with …

Polymyxins are valuable antimicrobials for the management of multidrug-resistant Gram-
negative bacteria; however, nephrotoxicity associated with these drugs is a very common …

Polymyxins are last-resort antibiotics re-emerged to treat infections caused by multidrug
resistant (MDR) and extensively drug-resistant (XDR) Gram-negative bacterial infections …

Increasing incidence of resistance of gram-negative bacteria against even newer antibiotic
including carbapenem has generated interest in the old antibiotic colistin, which are being …

The emergence of multidrug-resistant Acinetobacter baumannii is a major concern to
healthcare providers and facilities in many parts of the world. This bacterial pathogen is …

Objectives The objectives of this study were to assess risk factors for acute kidney injury
(AKI) in patients treated with polymyxin B, a last resort antibiotic against Gram-negative …

Introduction: The emergence of multidrug-resistant gram-negative bacteria has led to the
increasing use of polymyxins. Nephrotoxicity and, to a lesser degree, neurotoxicity occur …

Background. Critically ill patients with severe sepsis or septic shock may need relatively high
colistin daily doses for efficacy against multidrug-resistant and extensively drug-resistant …

Colistin and polymyxin B are increasingly reintroduced in clinical practice due to the
absence of effective antibiotics for the treatment of emerging infections caused by gram …