Duchenne muscular dystrophy is a lethal muscle-wasting disease that affects boys.
Mutations in the dystrophin gene result in the absence of the dystrophin glycoprotein …

In Duchenne muscular dystrophy patients, the pathological hallmark of the disease, namely,
the chronic accumulation of sclerotic scar tissue in the interstitial space of skeletal muscle is …

Mdx mouse, the animal model of Duchenne muscular dystrophy, develops an X‐linked
recessive inflammatory myopathy with an apparent sustained capacity for muscle …

Despite over 3,000 articles published on dystrophin in the last 15 years, the reasons
underlying the progression of the human disease, differential muscle involvement, and …

Mdx mouse, the animal model of Duchenne muscular dystrophy, lacks dystrophin and
develops an X-linked recessive inflammatory myopathy characterized by degeneration of …

Background ATL1102 is a 2'MOE gapmer antisense oligonucleotide to the CD49d alpha
subunit of VLA-4, inhibiting expression of CD49d on lymphocytes, reducing survival …

Matrix metalloproteases (MMPs) are key regulatory molecules in the formation, remodeling,
and degradation of extracellular matrix components in both physiological and pathological …

Background Duchenne muscular dystrophy (DMD) is caused by mutations in the dystrophin
gene. The immune inflammatory response also contributes to disease progression in DMD …

Background ATL1102 is a 2'MOE gapmer antisense oligonucleotide to the CD49d alpha
subunit of VLA-4. ATL1102 inhibits expression of CD49d on lymphocytes, thereby reducing …

The lymphatic vessels have been implicated in maintenance of interstitial fluid homeostasis
and immune responses, and pathological conditions including inflammation, wound healing …