Chiral chromatography method screening strategies: past, present and future

A Tarafder, L Miller - Journal of Chromatography A, 2021 - Elsevier
Method screening is an integral part of chromatographic method development for the
separation of racemates. Due to the highly complex retention mechanism of a chiral …

State-of-the-art and recent developments of immobilized polysaccharide-based chiral stationary phases for enantioseparations by high-performance liquid …

JM Padró, S Keunchkarian - Microchemical Journal, 2018 - Elsevier
Polysaccharide-based chiral stationary phases have been recognized as one of the most
powerful ones for high performance liquid chromatography (HPLC) separations of chiral …

α-Aminoazoles/azines: key reaction partners for multicomponent reactions

S Imtiaz, S Banoo - RSC advances, 2021 - pubs.rsc.org
Aromatic α-aminoazaheterocycles are the focus of significant investigations and exploration
by researchers owing to their key role in diverse biological and physiological processes. The …

Strategy for large-scale isolation of enantiomers in drug discovery

H Leek, L Thunberg, AC Jonson, K Öhlén… - Drug Discovery …, 2017 - Elsevier
Highlights•SFC is a superior separation technique for isolation of enantiomers.•A crucial
factor for success in SFC is solubility of the compound in the mobile phase.•Extraction …

Deep eutectic solvent immobilized on SBA-15 as a novel separable catalyst for one-pot three-component Mannich reaction

N Azizi, M Edrisi - Microporous and Mesoporous Materials, 2017 - Elsevier
An environmentally friendly and recyclable nanocomposite (HNMPCl/ZnCl 2/SBA-15) was
prepared by impregnation of N-methylpyrrolidonium-zinc chloride based deep eutectic …

Method screening strategies of stereoisomers of compounds with multiple chiral centers and a single chiral center

J Lin, C Tsang, R Lieu, K Zhang - Journal of Chromatography A, 2020 - Elsevier
Abstract Analysis and control of stereoisomers is a major task in pharmaceutical analysis,
and is a greater challenge when compounds with multiple chiral centers (MCC) are …

[HTML][HTML] Chirality and concentration detection of biomolecules based on spin Hall effect of light

J Xiao, T Tang, X Liang, K Liu, Y Tang, J Li, C Li - Physics Letters A, 2021 - Elsevier
The chirality and concentration of biomolecules can be simultaneously determined by weak
measurement techniques through spin Hall effect of light (SHEL) effect, which is theoretically …

The composition of the mobile phase affects the dynamic chiral recognition of drug molecules by the chiral stationary phase

B Zhao, PA Oroskar, X Wang, D House, A Oroskar… - Langmuir, 2017 - ACS Publications
More than half of all pharmaceuticals are chiral compounds. Although the enantiomers of
chiral compounds have the same chemical structure, they can exhibit marked differences in …

Enantio-resolution of some chiral sulfoxide drugs on amylose and cellulose-based stationary phases: Elution order, absolute configuration and chiral mechanism …

K Addadi, K Sekkoum, N Belboukhari… - Microchemical …, 2023 - Elsevier
The enantio-separation of three chiral sulfoxide drugs (omeprazole, pantoprazole, and
lansoprazole) was achieved on Chiralpak® AS-3R column with acetonitrile‐water (65: 35) at …

A comparison of chiral resolution of antifungal agents on different polysaccharide chiral columns under various mobile phase modes: Application in the biological …

I Ali, N Boumoua, K Sekkoum, N Belboukhari… - … of Chromatography B, 2021 - Elsevier
The current article describes the chiral separation of tioconazole, miconazole, isoconazole,
sertaconazole and terconazole, with Lux i-Cellulose 5 and Lux i-Amylose-1 chiral columns …