Tumor cells are characterized by uncontrolled growth, invasion to surrounding tissues, and
metastatic spread to distant sites. Mortality from cancer is often due to metastasis since …

Integrins play an important role in cell adhesion by linking the cytoskeleton of cells to
components in the extracellular matrix. In this capacity, integrins cooperate with different cell …

In a recently developed human breast cancer model, treatment of tumor cells in a 3-
dimensional culture with inhibitory β1-integrin antibody or its Fab fragments led to a striking …

Aberrant microenvironments and loss of balance in cell-extracellular matrix signaling are
associated with breast cancer invasion, metastasis, and resistance to therapy. We have …

Metastasis plays a major role in morbidity and mortality from breast cancer. Differences in
the incidence and mortality of breast cancer between societies suggest that environmental …

The glycoprotein bovine lactadherin (formerly known as PAS-6/7) comprises two EGF-like
domains and two C-like domains found in blood clotting factors V and VIII. Bovine …

Background. The value of surgical staging and treatment of the axillary lymph nodes with
either surgery or radiotherapy in the initial management of patients with Stage I or II invasive …

La marrie extracellulaire (MEC) est un des principaux régulateurs du développement et de
l'homéostasie tissulaires. Des études à l'aide de systèmes de microenvironnements …

Within the integrin family of cell adhesion receptors, integrins α3β1, α6β1, α6β4 and α7β1
make up a laminin-binding subfamily. The literature is divided on the role of these laminin …

The changes in tissue architecture that accompany the development of breast cancer have
been the focus of investigations aimed at developing new cancer therapeutics. As we learn …