Idiopathic pulmonary fibrosis: Current and future treatment

DS Glass, D Grossfeld, HA Renna… - The clinical …, 2022 - Wiley Online Library
Objectives Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic lung disease characterized
by dry cough, fatigue, and progressive exertional dyspnea. Lung parenchyma and …

Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis

THG Phan, P Paliogiannis, GK Nasrallah… - Cellular and Molecular …, 2021 - Springer
Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …

Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis

TS Adams, JC Schupp, S Poli, EA Ayaub… - Science …, 2020 - science.org
We provide a single-cell atlas of idiopathic pulmonary fibrosis (IPF), a fatal interstitial lung
disease, by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 …

Alveolar epithelial type II cells as drivers of lung fibrosis in idiopathic pulmonary fibrosis

T Parimon, C Yao, BR Stripp, PW Noble… - International journal of …, 2020 - mdpi.com
Alveolar epithelial type II cells (AT2) are a heterogeneous population that have critical
secretory and regenerative roles in the alveolus to maintain lung homeostasis. However …

Progressive pulmonary fibrosis is caused by elevated mechanical tension on alveolar stem cells

H Wu, Y Yu, H Huang, Y Hu, S Fu, Z Wang, M Shi… - Cell, 2020 - cell.com
Fibrosis can develop in most organs and causes organ failure. The most common type of
lung fibrosis is known as idiopathic pulmonary fibrosis, in which fibrosis starts at the lung …

Idiopathic pulmonary fibrosis (IPF): an overview

SL Barratt, A Creamer, C Hayton… - Journal of clinical …, 2018 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterised by chronic,
progressive scarring of the lungs and the pathological hallmark of usual interstitial …

PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis

M Bueno, YC Lai, Y Romero, J Brands… - The Journal of …, 2015 - Am Soc Clin Investig
Although aging is a known risk factor for idiopathic pulmonary fibrosis (IPF), the pathogenic
mechanisms that underlie the effects of advancing age remain largely unexplained. Some …

The leading role of epithelial cells in the pathogenesis of idiopathic pulmonary fibrosis

M Selman, A Pardo - Cellular signalling, 2020 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a relentlessly progressive and devastating interstitial
lung disease of unknown etiology, where the normal lung architecture is lost and replaced …

The role of immune and inflammatory cells in idiopathic pulmonary fibrosis

O Desai, J Winkler, M Minasyan, EL Herzog - Frontiers in medicine, 2018 - frontiersin.org
The contribution of the immune system to idiopathic pulmonary fibrosis (IPF) remains poorly
understood. While most sources agree that IPF does not result from a primary …

[HTML][HTML] Recent developments in myofibroblast biology: paradigms for connective tissue remodeling

B Hinz, SH Phan, VJ Thannickal, M Prunotto… - The American journal of …, 2012 - Elsevier
The discovery of the myofibroblast has opened new perspectives for the comprehension of
the biological mechanisms involved in wound healing and fibrotic diseases. In recent years …