Mechanistic insights into precursor messenger RNA splicing by the spliceosome
Y Shi - Nature reviews Molecular cell biology, 2017 - nature.com
Precursor messenger RNA (pre-mRNA) splicing is an essential step in the flow of
information from DNA to protein in all eukaryotes. Research over the past four decades has …
information from DNA to protein in all eukaryotes. Research over the past four decades has …
[HTML][HTML] The noncoding RNA revolution—trashing old rules to forge new ones
TR Cech, JA Steitz - Cell, 2014 - cell.com
Noncoding RNAs (ncRNAs) accomplish a remarkable variety of biological functions. They
regulate gene expression at the levels of transcription, RNA processing, and translation …
regulate gene expression at the levels of transcription, RNA processing, and translation …
A day in the life of the spliceosome
One of the most amazing findings in molecular biology was the discovery that eukaryotic
genes are discontinuous, with coding DNA being interrupted by stretches of non-coding …
genes are discontinuous, with coding DNA being interrupted by stretches of non-coding …
RNA-RNA interactions enable specific targeting of noncoding RNAs to nascent Pre-mRNAs and chromatin sites
Intermolecular RNA-RNA interactions are used by many noncoding RNAs (ncRNAs) to
achieve their diverse functions. To identify these contacts, we developed a method based on …
achieve their diverse functions. To identify these contacts, we developed a method based on …
How we think about targeting RNA with small molecules
MG Costales, JL Childs-Disney, HS Haniff… - Journal of medicinal …, 2020 - ACS Publications
RNA offers nearly unlimited potential as a target for small molecule chemical probes and
lead medicines. Many RNAs fold into structures that can be selectively targeted with small …
lead medicines. Many RNAs fold into structures that can be selectively targeted with small …
Before enzymes and templates: theory of surface metabolism
G Wächtershäuser - Microbiological reviews, 1988 - Am Soc Microbiol
Woese's three kingdoms (161-166) constitute the deepest branching of the known
biosphere. His suggestion to search for a common ancestor has led to the present …
biosphere. His suggestion to search for a common ancestor has led to the present …
RNA processing and its regulation: global insights into biological networks
DD Licatalosi, RB Darnell - Nature Reviews Genetics, 2010 - nature.com
In recent years views of eukaryotic gene expression have been transformed by the finding
that enormous diversity can be generated at the RNA level. Advances in technologies for …
that enormous diversity can be generated at the RNA level. Advances in technologies for …
A major developmental transition in early Xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage
J Newport, M Kirschner - Cell, 1982 - cell.com
The Xenopus embryo undergoes 12 rapid synchronous cleavages followed by a period of
slower asynchronous divisions more typical of somatic cells. This change in cell cleavage …
slower asynchronous divisions more typical of somatic cells. This change in cell cleavage …
Engineered nucleic acids encoding a modified erythropoietin and their expression
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
46147671&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
46147671&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
U1 snRNP regulates chromatin retention of noncoding RNAs
Long noncoding RNAs (lncRNAs) and promoter-or enhancer-associated unstable
transcripts locate preferentially to chromatin, where some regulate chromatin structure …
transcripts locate preferentially to chromatin, where some regulate chromatin structure …