The increasing prevalence of older-age people in our society represents the culmination of
centuries of medical, scientific, and social endeavors. At least in Western society, now …

Several studies have processed conceivable evidence for the vital role of Signal Transducer
and Activator of Transcription 3 (STAT3) in cancer transformation and carcinogenesis …

Obesity is a major driver of cancer, especially hepatocellular carcinoma (HCC). The
prevailing view is that non-alcoholic steatohepatitis (NASH) and fibrosis or cirrhosis are …

Endothelial to mesenchymal transition (EndMT) plays a major role during development, and
also contributes to several adult cardiovascular diseases. Importantly, mesenchymal cells …

Veins grafted into an arterial environment undergo a complex vascular remodeling process.
Pathologic vascular remodeling often results in stenosed or occluded conduit grafts …

The periosteum is critical for bone maintenance and healing. However, the in vivo identity
and specific regulatory mechanisms of adult periosteum-resident skeletal stem cells are …

Inborn errors of the genes encoding two of the four human JAKs (JAK3 and TYK2) and three
of the six human STATs (STAT1, STAT3, and STAT5B) have been described. We review the …

Breast cancer metastasis involves lymphatic dissemination in addition to hematogenous
spreading. Although stromal lymphatic vessels (LVs) serve as initial metastatic routes, roles …

Far from being merely a passive cholesterol accumulation within the arterial wall, the
development of atherosclerosis is currently known to imply both inflammation and immune …

DNA methylation plays critical roles in vascular pathology of pulmonary hypertension (PH).
The underlying mechanism, however, remains undetermined. Here, we demonstrate that …