Abstract 'Autophagy'refers to an evolutionarily conserved process through which cellular
contents, such as damaged organelles and protein aggregates, are delivered to lysosomes …

Mitochondria are central hubs of cellular metabolism that also play key roles in signaling
and disease. It is therefore fundamentally important that mitochondrial quality and activity …

Cargo sequestration is a fundamental step of selective autophagy in which cells generate a
double-membrane structure termed an" autophagosome" on the surface of cargoes. NDP52 …

The structures and functions of organelles in cells depend on each other but have not been
systematically explored. We established stable knockout cell lines of peroxisomal, Golgi and …

As the autophagosome forms, its membrane surface area expands rapidly, while its volume
is kept low. Protein-mediated transfer of lipids from another organelle to the autophagosome …

We report that lysosomal damage is a hitherto unknown inducer of stress granule (SG)
formation and that the process termed membrane atg8ylation coordinates SG formation with …

The covalent attachment of ubiquitin is a common regulatory mechanism in various proteins.
Although it has long been thought that the substrates of ubiquitination are limited to proteins …

Eukaryotes initiate autophagy when facing environmental changes such as a lack of
external nutrients. However, the mechanisms of autophagy initiation are still not fully …

Aging is one of the critical factors to impair liver regeneration leading to a high incidence of
severe complications after hepatic surgery in the elderly population without any effective …

Zinc, an essential trace mineral, plays a pivotal role in cell proliferation, maintenance of
redox homeostasis, apoptosis, and aging. Serum zinc concentrations are reduced in …