Blood vessels form extensive networks that nurture all tissues in the body. Abnormal vessel
growth and function are hallmarks of cancer and ischemic and inflammatory diseases, and …

The vertebrate vasculature forms an extensive branched network of blood vessels that
supplies tissues with nutrients and oxygen. During vascular development, coordinated …

INTRODUCTION Vertebrate development comprises multiple complex morphogenetic
processes that shape the embryonic body plan through self-organization of pluripotent stem …

Yes-associated protein (YAP) is regulated by mechanical cues via the interaction of the
Hippo pathway with cytoskeleton. Previous studies showed that YAP plays a role in …

How vascular tubes build, maintain and adapt continuously perfused lumens to meet local
metabolic needs remains poorly understood. Recent studies showed that blood flow itself …

Epithelial cells have an apical–basolateral axis of polarity, which is required for epithelial
functions including barrier formation, vectorial ion transport and sensory perception. Here …

The Rho subfamily members of Rho GTPases, RhoA, RhoB, and RhoC, are key regulators
of signal transduction in a variety of cellular processes, including regulation of actomyosin …

Organ formation and growth requires cells to organize into properly patterned three-
dimensional architectures. Network formation within the vertebrate vascular system is driven …

Identified as a major downstream effector of the small GTPase RhoA, Rho-associated coiled-
coil kinase (ROCK) is a versatile regulator of multiple cellular processes. Angiogenesis, the …

Endothelial cell–cell adherens junctions (AJs) supervise fundamental vascular functions,
such as the control of permeability and transmigration of circulating leukocytes, and the …