EJ Tsai, DA Kass - Pharmacology & therapeutics, 2009 - Elsevier
Cyclic guanosine 3', 5'-monophosphate (cGMP) mediates a wide spectrum of physiologic processes in multiple cell types within the cardiovascular system. Dysfunctional signaling at …
B DeBosch, I Treskov, TS Lupu, C Weinheimer… - Circulation, 2006 - Am Heart Assoc
Background—Postnatal growth of the heart chiefly involves nonproliferative cardiomyocyte enlargement. Cardiac hypertrophy exists in a “physiological” form that is an adaptive …
M Zaccolo, MA Movsesian - Circulation research, 2007 - Am Heart Assoc
Cyclic nucleotide phosphodiesterases regulate cAMP-mediated signaling by controlling intracellular cAMP content. The cAMP-hydrolyzing activity of several families of cyclic …
Heart failure is one of the leading causes of mortality in the western world and encompasses a wide spectrum of cardiac pathologies. When the heart experiences extended periods of …
Background—Cyclic guanosine monophosphate (cGMP) is the common second messenger for the cardiovascular effects of nitric oxide (NO) and natriuretic peptides, such as atrial or …
TG Von Lueder, SJ Sangaralingham… - Circulation: Heart …, 2013 - Am Heart Assoc
TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist Trial) trial for efficacy in HF with preserved ejection fraction (HFPEF), a disease …
Increasing evidence suggests that natriuretic peptides (NPs) play diverse roles in mammals, including renal hemodynamics, neuroendocrine, and cardiovascular functions. Collectively …
P Li, D Wang, J Lucas, S Oparil, D Xing, X Cao… - Circulation …, 2008 - Am Heart Assoc
This study tested the hypothesis that activation of atrial natriuretic peptide (ANP)/cGMP/protein kinase G signaling inhibits transforming growth factor (TGF)-β1 …
T Soeki, I Kishimoto, H Okumura, T Tokudome… - Journal of the American …, 2005 - jacc.org
Objectives: We assessed the hypothesis that in vivo administration of C-type natriuretic peptide (CNP) might attenuate cardiac remodeling after myocardial infarction (MI) through its …