Adipokines, diabetes and atherosclerosis: an inflammatory association

LC Freitas Lima, VA Braga… - Frontiers in …, 2015 - frontiersin.org
Cardiovascular diseases can be considered the most important cause of death in diabetic
population and diabetes can in turn increase the risk of cardiovascular events. Inflammation …

Increased ROS production and DNA damage in monocytes are biomarkers of aging and atherosclerosis

TA Jacinto, GS Meireles, AT Dias, R Aires, ML Porto… - Biological research, 2018 - Springer
Background New evidence demonstrates that aging and dyslipidemia are closely
associated with oxidative stress, DNA damage and apoptosis in some cells and …

Renoprotective, anti-oxidative and anti-apoptotic effects of oral low-dose quercetin in the C57BL/6J model of diabetic nephropathy

IBS Gomes, ML Porto, MCLFS Santos… - Lipids in Health and …, 2014 - Springer
Background Diabetic nephropathy (DN) is one of the major causes of end-stage renal
disease in diabetic patients. Increasing evidence from studies in the rodents has suggested …

Novel Therapeutic Targets for Phosphodiesterase 5 Inhibitors: current state-of-the-art on systemic arterial hypertension and atherosclerosis

EC Vasquez, AL Gava, JB Graceli… - Current …, 2016 - ingentaconnect.com
The usefulness of selective inhibitors of phosphodiesterase 5 (PDE5) is well known, first for
the treatment of male erectile dysfunction and more recently for pulmonary hypertension …

Gastroprotective effect of oral kefir on indomethacin-induced acute gastric lesions in mice: Impact on oxidative stress

KRM Barboza, LZ Coco, GM Alves, B Peters… - Life Sciences, 2018 - Elsevier
Aims This study investigated the gastroprotective effects and the systemic oxidative status of
oral kefir pretreatment in albino mice submitted to acute gastric ulcer induced by …

Solanum trilobatum L. Ameliorate Thioacetamide-Induced Oxidative Stress and Hepatic Damage in Albino Rats

K Ganesan, K Sukalingam, B Xu - Antioxidants, 2017 - mdpi.com
Solanum trilobatum L.(Solanaceae) has been well known as nightshade, commonly used by
diverse populations to heal several disorders. Earlier studies in Solanum trilobatum were …

Sildenafil ameliorates oxidative stress and DNA damage in the stenotic kidneys in mice with renovascular hypertension

AT Dias, BP Rodrigues, ML Porto, AL Gava… - Journal of translational …, 2014 - Springer
Background Oxidative stress and DNA damage have been implicated in the pathogenesis of
renovascular hypertension induced by renal artery stenosis in the two-kidney, one-clip …

Effects of tobacco smoking during pregnancy on oxidative stress in the umbilical cord and mononuclear blood cells of neonates

EAO Rua, ML Porto, JPL Ramos, BV Nogueira… - Journal of biomedical …, 2014 - Springer
Background Although cigarette smoke is known to be a complex mixture of over 4000
substances that can lead to damage through active or passive smoking, its mechanisms and …

A non-aggregated silicon (IV) phthalocyanine-lactose conjugate for photodynamic therapy

D Li, QY Hu, XZ Wang, X Li, JQ Hu, BY Zheng… - Bioorganic & Medicinal …, 2020 - Elsevier
To develop a highly efficient photosensitizer for photodynamic therapy (PDT), we have
designed and synthesized a phthalocyanine-lactose conjugate (Pc-Lac) through axial …

Silymarin protects against radiocontrast-induced nephropathy in mice

V de Souza Santos, B Peters, LZ Côco, GM Alves… - Life sciences, 2019 - Elsevier
Silymarin, an extract from Silybum marianum (milk thistle) containing a standardized mixture
of flavonolignans that ameliorates some types of liver disease and, more recently, kidney …