The worldwide incidence of obesity and its sequelae, such as type 2 diabetes mellitus, have
reached pandemic levels. Central to the development of these metabolic disorders is …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Excessive fat accumulation in the body causes overweight and obesity. To date, research
has confirmed that there are two types of adipose tissue with opposing functions: lipid …

The issue under discussion here is whether a decrease in the degree of UCP1 activity (and
brown adipose tissue activity in general) could be a cause of obesity in humans. This …

The mechanisms underlying glucocorticoid (GC)-induced obesity are poorly understood.
Macrophages are the primary targets by which GCs exert pharmacological effects and …

Body homeostasis is predominantly controlled by hormones secreted by endocrine organs.
The central nervous system contains several important endocrine structures, including the …

Olfactory cues are vital for prey animals like rodents to perceive and evade predators. Stress-
induced hyperthermia, via brown adipose tissue (BAT) thermogenesis, boosts physical …

Brown adipocytes store metabolic energy as triglycerides (TGs) in lipid droplets (LDs). Fatty
acids released from brown adipocyte LDs by lipolysis are thought to activate and fuel UCP1 …

Glucocorticoids (GCs) are hormones that aid the body under stress by regulating glucose
and free fatty acids. GCs maintain energy homeostasis in multiple tissues, including those in …

Due to extremely poor systemic bioavailability, the mechanism by which curcumin increases
energy expenditure remains unelucidated. Accumulating evidence suggests a strong …