The oxygen carried inside plasma performs differently than the oxygen carried inside red
cells. Only 0.13–0.3 mL of oxygen in 100 mL of blood is available inside plasma while 14 …

A pyridoxalated hemoglobin‐polyoxyethylene conjugate (PHP) is an oxygen carrier
prepared from outdated human red cells through chemical modifications of hemoglobin …

A pyridoxalated-hemoglobin-polyoxyethylene conjugate (PHP) was developed from
outdated human red cell hemoglobin through chemical modifications. The PHP has a mean …

Background One of the perceived advantages of a hemoglobin-based blood substitute is the
provision of oxygen-carrying capacity. Although the hemodynamic response to the infusion …

A need is strongly recognized for a safe red cell substitute that can carry oxygen to the
hypoxic tissues of an anemic body. Banked blood is in short supply because of mounting …

Background Previous research suggested that splanchnic hypoperfusion occurs after
resuscitation with certain acellular hemoglobin solutions. We examined the influence of …

While the clinical results of orthotopic liver transplantation have greatly improved, the
viability of liver grafts and extension of the safe time for preservation are necessary factors in …

Prevention of hyperacute rejection is a difficult and unsolved problem in
xenotransplantation. Natural antibodies and complement activation have been known to …

A stabilized form of hemoglobin as oxygen‐carrying macromolecules was developed. It had
an approximately 90,000 dalton molecular weight, and its intravascular half‐life was 36 h. Its …

PHP, mean molecular weight of approximately 90,000 daltons, is produced by chemical
modifications of outdated human red cell hemoglobin (Hb). The P50 value of PHP is 22±0.7 …