DNA end resection: mechanism and control
P Cejka, LS Symington - Annual review of genetics, 2021 - annualreviews.org
DNA double-strand breaks (DSBs) are cytotoxic lesions that threaten genome integrity and
cell viability. Typically, cells repair DSBs by either nonhomologous end joining (NHEJ) or …
cell viability. Typically, cells repair DSBs by either nonhomologous end joining (NHEJ) or …
Main steps in DNA double-strand break repair: an introduction to homologous recombination and related processes
DNA double-strand breaks arise accidentally upon exposure of DNA to radiation and
chemicals or result from faulty DNA metabolic processes. DNA breaks can also be …
chemicals or result from faulty DNA metabolic processes. DNA breaks can also be …
Nuclear ARP2/3 drives DNA break clustering for homology-directed repair
DNA double-strand breaks repaired by non-homologous end joining display limited DNA
end-processing and chromosomal mobility. By contrast, double-strand breaks undergoing …
end-processing and chromosomal mobility. By contrast, double-strand breaks undergoing …
Chromatin and nucleosome dynamics in DNA damage and repair
Chromatin is organized into higher-order structures that form subcompartments in
interphase nuclei. Different categories of specialized enzymes act on chromatin and …
interphase nuclei. Different categories of specialized enzymes act on chromatin and …
Nuclear F-actin and myosins drive relocalization of heterochromatic breaks
Heterochromatin mainly comprises repeated DNA sequences that are prone to ectopic
recombination. In Drosophila cells,'safe'repair of heterochromatic double-strand breaks by …
recombination. In Drosophila cells,'safe'repair of heterochromatic double-strand breaks by …
An overview of the molecular mechanisms of recombinational DNA repair
SC Kowalczykowski - Cold Spring Harbor Perspectives …, 2015 - cshperspectives.cshlp.org
Recombinational DNA repair is a universal aspect of DNA metabolism and is essential for
genomic integrity. It is a template-directed process that uses a second chromosomal copy …
genomic integrity. It is a template-directed process that uses a second chromosomal copy …
Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization
Nuclear actin-based movements have been shown to orchestrate clustering of DNA double-
strand breaks (DSBs) into homology-directed repair domains. Here we describe multiscale …
strand breaks (DSBs) into homology-directed repair domains. Here we describe multiscale …
Repair of strand breaks by homologous recombination
M Jasin, R Rothstein - Cold Spring Harbor perspectives …, 2013 - cshperspectives.cshlp.org
In this review, we discuss the repair of DNA double-strand breaks (DSBs) using a
homologous DNA sequence (ie, homologous recombination [HR]), focusing mainly on yeast …
homologous DNA sequence (ie, homologous recombination [HR]), focusing mainly on yeast …
Is non-homologous end-joining really an inherently error-prone process?
M Bétermier, P Bertrand, BS Lopez - PLoS genetics, 2014 - journals.plos.org
DNA double-strand breaks (DSBs) are harmful lesions leading to genomic instability or
diversity. Non-homologous end-joining (NHEJ) is a prominent DSB repair pathway, which …
diversity. Non-homologous end-joining (NHEJ) is a prominent DSB repair pathway, which …
Interchromosomal homology searches drive directional ALT telomere movement and synapsis
Telomere length maintenance is a requisite feature of cellular immortalization and a
hallmark of human cancer. While most human cancers express telomerase activity,∼ 10 …
hallmark of human cancer. While most human cancers express telomerase activity,∼ 10 …