Temperature is a universal cue and regulates many essential processes ranging from
enzymatic reactions to species migration. Due to the profound impact of temperature on …

TRPA1 is a non‐selective cation channel expressed in mammalian peripheral pain
receptors, with a major role in chemonociception. TRPA1 has also been implicated in …

Transient receptor potential vanilloid member 1 (TRPV1) is a Ca2+-permeable cation
channel that serves as the primary heat and capsaicin sensor in humans. Using cryo-EM, we …

Biological ion channels are molecular gatekeepers that control transport across cell
membranes. Recreating the functional principle of such systems and extending it beyond …

Both electric and chemical synapses play an important role in receiving and propagating
signals, and thus an isolated neuron and neurons in networks can be activated to trigger …

Piezo1 channels are essential mechanically activated ion channels in vertebrates. Their
selective activation by the synthetic chemical activator Yoda1 opened new avenues to probe …

We present structures of mouse TRPV3 in temperature-dependent open, closed and
intermediate states that suggest two-step activation of TRPV3 by heat. During the strongly …

The ability to tune ionic permeation across nanoscale pores profoundly impacts diverse
fields from nanofluidic computing to drug delivery. Here, we take advantage of complex …

Mechanical and thermal activation of ion channels is central to touch, thermosensation, and
pain. The TRAAK/TREK K 2P potassium channel subfamily produces background currents …

Nanopores are powerful nanodevices that puncture semifluid membranes to enable
transport of molecular matter across biological or synthetic thin layers. Advanced nanopores …