The raison d'être of meiosis is shuffling of genetic information via Mendelian segregation
and, within individual chromosomes, by DNA crossing-over. These outcomes are enabled …

Cohesin is an evolutionary conserved multi‐protein complex that plays a pivotal role in
chromosome dynamics. It plays a role both in sister chromatid cohesion and in establishing …

During meiotic prophase, chromosomes organise into a series of chromatin loops
emanating from a proteinaceous axis, but the mechanisms of assembly remain unclear …

Meiocytes organize higher-order chromosome structures comprising arrays of chromatin
loops organized at their bases by linear axes. As meiotic prophase progresses, the axes of …

Meiosis is critically different from mitosis in that during meiosis, pairing and segregation of
homologous chromosomes occur. During meiosis, the morphology of sister chromatids …

Mitosis and meiosis both rely on cohesin, which embraces the sister chromatids and plays a
crucial role for the faithful distribution of chromosomes to daughter cells. Prior to the …

Condensins and cohesins are highly conserved complexes that tether together DNA loci
within a single DNA molecule to produce DNA loops. Condensin and cohesin structures …

Meiotic recombination is integrated into and regulated by meiotic chromosomes, which is
organized as loop/axis architecture. However, the regulation of chromosome organization is …

We have explored the meiotic roles of cohesin modulators Pds5 and Rad61/Wapl, in relation
to one another, and to meiotic kleisin Rec8, for homolog pairing, all physically definable …

Cohesin is essential for genome folding and inheritance. In somatic cells, these functions
are both mediated by Scc1-cohesin, which in mitosis is released from chromosomes by …