Astrocytes are a population of cells with distinctive morphological and functional
characteristics that differ within specific areas of the brain. Postnatally, astrocyte progenitors …

Existing therapies for epilepsy are primarily symptomatic and target mechanisms of neuronal
transmission in order to restore the excitatory/inhibitory imbalance in the brain after seizures …

Hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1) due to
mutations in genes along the PI3K-mTOR pathway and the GATOR1 complex causes a …

Introduction: Epileptic disorders are a heterogeneous group of medical conditions with
epilepsy as the common denominator. Genetic causes, electro-clinical features, and …

Brain somatic mutations confer genomic diversity in the human brain and cause
neurodevelopmental disorders. Recently, brain somatic activating mutations in MTOR have …

Gene variants that hyperactivate PI3K-mTOR signaling in the brain lead to epilepsy and
cortical malformations in humans. Some gene variants associated with these pathologies …

Approximately 22% of Alzheimer's disease (AD) patients suffer from seizures, and the co-
occurrence of seizures and epileptiform activity exacerbates AD pathology and related …

Glioblastoma (GBM) is characterized by fast-growing cells, genetic and phenotypic
heterogeneity, and radio-chemo-therapy resistance, contributing to its dismal prognosis …

Objectives Dysfunctional connectivity and preexisting structural abnormalities of central
autonomic network (CAN) regions have been shown on magnetic resonance imaging (MRI) …

Gene variants that hyperactivate PI3K-mTOR signaling in the brain lead to epilepsy and
cortical malformations in humans. Some gene variants associated with these pathologies …