Cancer systems epidemiology: Overcoming misconceptions and integrating systems
approaches into cancer research | PLOS Medicine Skip to main content Advertisement …

Cancer originates from somatic cells that have accumulated mutations. These mutations
alter the phenotype of the cells, allowing them to escape homeostatic regulation that …

Cell lineages accumulate somatic mutations during organismal development, potentially
leading to pathological states. The rate of somatic evolution within a cell population can vary …

In cancer treatment, adaptive therapy holds promise for delaying the onset of recurrence
through regulating the competition between drug-sensitive and drug-resistant cells. Adaptive …