Tight junctions (TJs) play an important role in intestinal barrier function. TJs in intestinal
epithelial cells are composed of different junctional molecules, such as claudin and …

Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the intestine
that compromises the patients' life quality and requires sustained pharmacological and …

Intestinal epithelial cells (IECs) lining the gastrointestinal tract establish a barrier between
external environments and the internal milieu. An intact intestinal barrier maintains gut …

Phenolic compounds represent a diverse group of phytochemicals whose intake is
associated with a wide spectrum of health benefits. As consequence of their low …

TLR4/NF-κB is a key inflammatory signaling transduction pathway, closely involved in cell
differentiation, proliferation, apoptosis, and pro-inflammatory response. Toll like receptor 4 …

Citrus flavanones, with hesperidin and naringin as the most abundant representatives, have
various beneficial effects, including anti-oxidative and anti-inflammatory activities. Evidence …

Flavonoids are polyphenolic compounds produced by plants and delivered to the human
body through food. Although the epidemiological analyses of large human populations did …

Increasing evidence links intestinal permeability (IP), a feature of the intestinal barrier, to
several pathological or dysfunctional conditions. Several host and environmental factors …

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of intestinal mucosa
and submucosa, characterized by the disruption of the intestinal epithelial barrier, increased …

The intestinal epithelium acts as a key defensive barrier that protects internal organs from
the detrimental gut environment. The homeostasis of the gut epithelium may be altered by …