Glycomics is a broad and emerging scientific discipline focused on defining the structures
and functional roles of glycans in biological systems. The staggering complexity of the …

Carbohydrates are central players in a number of important biological processes including
cell signaling, cell adhesion, and the regulation of biochemical pathways. Unlike nucleic …

Most methods for the analysis of oligosaccharides from biological sources require a glycan
derivatization step: glycans may be derivatized to introduce a chromophore or fluorophore …

1.1. General Considerations Structural intricacies of carbohydrate molecules and their
propensity to form varied linkages, substitutions, and branching patterns have fascinated …

Glycosylation is an important posttranslational modifier of proteins and lipid conjugates
critical for the stability and function of these macromolecules. Particularly important are N …

Growing implications of glycosylation in physiological occurrences and human disease have
prompted intensive focus on revealing glycomic perturbations through absolute and relative …

The diversification of the chemical properties and biological functions of proteins is attained
through posttranslational modifications, such as glycosylation. Glycans, which are covalently …

Regulatory bodies worldwide consider N-glycosylation to be a critical quality attribute for
immunoglobulin G (IgG) and IgG-like therapeutics. This consideration is due to the …

N-Linked protein glycosylation is one of the most prevalent post-translational modifications
and is involved in essential cellular functions such as cell–cell interactions and cellular …

Carbohydrates encode biological information necessary for cellular function. The structural
diversity and complexity of these sugar residues have necessitated the creation of novel …