In recent decades, transient and highly reactive ortho-quinodimethanes (o-QDMs), ortho-
quinone methides (o-QMs) and aza-ortho-quinone methides (aza-o-QMs) have attracted …

Fungi are prolific producers of natural products, compounds which have had a large societal
impact as pharmaceuticals, mycotoxins, and agrochemicals. Despite the availability of over …

Abstract Long sought after [4+ 2] cyclases have sprouted up in numerous biosynthetic
pathways in recent years, raising hopes for biocatalytic solutions to cycloaddition catalysis …

Antibiotic resistance nowadays is spreading much faster than the introduction of new
antibiotics into clinical practice. There is an urgent need for potential compounds to combat …

Equisetin, a bioactive compound of marine origin, offers compelling inhibitory properties
against HIV-1 transcriptase. To gain comprehensive insights into the interaction of Equisetin …

Substituted cyclohexanes are common scaffolds found in both natural products and drug
molecules. Diels-Alderases that can efficiently catalyze intermolecular Diels-Alder reactions …

Abstract Enzymes catalyzing [4+ 2] cycloaddition have attracted increasing attention
because of their key roles in natural product biosynthesis. Here, we solved the X‐ray crystal …

Mammalian cells act as reservoirs of internalized bacteria to circumvent extracellular
antibacterial compounds, resulting in relapse and reinfection diseases. The intracellular …

Herein, we present a novel and ecofriendly biocatalytic approach for synthesizing
efinaconazole (7), a clinically used antifungal agent. This method involves utilizing …

Here, we provide structural insights into PyrE3, a flavin-dependent [4+ 2] cyclase that
catalyzes trans-decalin formation in the biosynthesis of pyrroindomycins. PyrE3 shares an …